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Oxandrolone(Oxandrin) is adrugcreated bySearle Laboratories, nowPfizer Inc.under the trademarkAnavar, and introduced into the US in 1964.

Oxandrolone is a syntheticanabolic steroidderived fromdihydrotestosteroneby substituting 2nd carbon atom for oxygen (O). It is widely known for its exceptionally small level of androgenicity accompanied by moderate anabolic effect. Although oxandrolone is a 17-alpha alkylated steroid, its liver toxicity is very small as well. Studies have showed that a daily dose of 20 mg oxandrolone used in the course of 12 weeks had only a negligible impact on the increase of liver enzymes[1][2]. As a DHT derivative, oxandrolone does notaromatize(convert to estrogen, which causesgynecomastiaor male breast tissue). It also does not significantly influence the body's normal testosterone production (HPTA axis) at low dosages (10 mg). When dosages are high, the human body reacts by reducing the production of LH (luteinizing hormone), thinkingendogenoustestosterone production is too high; this in turn eliminates further stimulation of Leydig cells in thetesticles, causingtesticular atrophy(shrinking). Oxandrolone used in a dose of 80 mg/day suppressed endogenous testosterone by 67% after 12 weeks of therapy[3].

The drug was prescribed to promote muscle regrowth in disorders which cause involuntary weight loss. It had also been shown to be partially successful in treating cases ofosteoporosis. However, in part due to bad publicity from its abuses bybodybuilders, production of Anavar was discontinued by Searle Laboratories in 1989. It was picked up by Bio-Technology General Corporation, nowSavient Pharmaceuticalswho, following successful clinical trials in 1995, released it under the tradename Oxandrin. As of 2009, it is the only drug marketed by the company.

It was subsequently approved fororphan drugstatus by theFood and Drug Administration(FDA) for treating alcoholic hepatitis,Turner syndrome, andweight losscaused byHIV. It is also indicated as an offset toprotein catabolismcaused by long-term administration ofcorticosteroids. In addition, the drug has shown positive results in treatinganemiaandhereditary angioedema. Because of its potential for abuse, it is categorized as aSchedule IIIcontrolled substance in the US.

In a randomized, double-blind study, patients with 40% total body surface areaburnswere selected to receive standard burn care plus oxandrolone, or without oxandrolone. Those treated with oxandrolone showed improved body composition, preservedmuscle massand reduced hospital stay time.[4]

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